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KMID : 0606920060140030166
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Biomolecules & Therapeutics
2006 Volume.14 No. 3 p.166 ~ p.170
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Effects of Three Compounds from Schizandrae Fructus and Uridine on Airway Mucin Secretion
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Heo Ho-Jin
Lee Hyun-Jae
Kim Cheol-su
Bae Ki-Hwan
Kim Yeong-Shik
Kang Sam-Sik
Seo Un-Kyo
Kim Yun-Hee
Park Yang-Chun
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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In this study, we investigated whether schizandrin, schizandrin-A and uridine affect mucin secretion from cultured airway epithelial cells and compared the potential activities of these agents with the inhibitory action on mucin secretion by poly-1-lysine (PLL) and the stimulatory action by adenosine triphosphate (ATP). Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows: schizandrin-A and uridine increased mucin secretion at the highest concentrations (2×10-4M - 10-3M). We conclude that schizandrin-A and uridine can stimulate mucin secretion via direct effect on airway mucin-secreting cells and suggest that these agents be further investigated for the potential use as mucoregulators during the treatment of chronic airway diseases.
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KEYWORD
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Airway mucin, Schizandrrin-A, Gomisin-A, Uridine
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